From chronic overnutrition to metaflammation and insulin resistance: adipose tissue and liver contributions
نویسندگان
چکیده
منابع مشابه
Adipose Tissue Inflammation and Insulin Resistance
A sustained increase in body mass, particularly fat mass, an unhealthy diet and a sedentary lifestyle trigger metabolic alterations such as metabolic syndrome, obesity, and type 2 diabetes mellitus (2DM). These metabolic conditions increase the cardiovascular disease risks and have become epidemic public health problems (Grundy 2002). Individuals who are overweight and obese are associated with...
متن کاملAdipose tissue and the insulin resistance syndrome.
Obesity is associated with insulin resistance. Insulin resistance underlies a constellation of adverse metabolic and physiological changes (the insulin resistance syndrome) which is a strong risk factor for development of type 2 diabetes and CHD. The present article discusses how accumulation of triacylglycerol in adipocytes can lead to deterioration of the responsiveness of glucose metabolism ...
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Obesity stimulates chronic inflammation in adipose tissue, which is associated with insulin resistance, although the underlying mechanism remains largely unknown. Here we showed that obesity-related adipocyte degeneration causes release of cell-free DNA (cfDNA), which promotes macrophage accumulation in adipose tissue via Toll-like receptor 9 (TLR9), originally known as a sensor of exogenous DN...
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Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294; Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL 35294 Department of Nutrition, University of Alabama at Birmingham, Birmingham, AL 35294 ...
متن کاملInsulin resistance causes inflammation in adipose tissue.
Obesity is a major risk factor for insulin resistance and type 2 diabetes. In adipose tissue, obesity-mediated insulin resistance correlates with the accumulation of proinflammatory macrophages and inflammation. However, the causal relationship of these events is unclear. Here, we report that obesity-induced insulin resistance in mice precedes macrophage accumulation and inflammation in adipose...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 2017
ISSN: 0014-5793
DOI: 10.1002/1873-3468.12742